Biological and Medicinal Chemistry

Sunday AM

BM2WCC-Room 8

Antioxidants and Oxidative Metabolism

Organizer(s) - Ed Krol
Chair(s) - Ed Krol and Jeffrey Atkinson

08:00 00007 Evolution of Antioxidant Design for Biological Targets *$Wright J.S., So R., Willmore W.G., Bal M.
08:20 00008 Souping-Up Vitamin E and New Insights in Peroxidation Chemistry *$Pratt D.A.
08:40 00009 Mechanism of Vitamin E Deposition and Pickup from Phospholipid Membranes by the Tocopherol Transfer Protein *$Atkinson J., Nava P., Frahm G., Cecchini M., Virgulti A., Zhang W.X., Manor D., Morley S.
09:00 00010 Design and Synthesis of a BODIPY-a-Tocopherol Adduct for Use as an Off/On Fluorescent Antioxidant Indicator Oleynik P., Ishihara Y., *$Cosa G.
09:20 00011 Antioxidant Properties and Oxidative Metabolism of Lignans from Flaxseed and Creosote Bush *$Krol E.S., Hosseinian F.S., Billinsky J.L., Muir A.D., Westcott N.D.
09:40 Coffee Break

10:00 Bernard Belleau Award Lecture presented by Masad Damha in WCC-Room 15

10:40 00012 New Fluorescent Sensors to Detect Reactive Oxygen Species in Biological Samples Heyne B., Ahmed S., Beddie C., *Scaiano J.C.
11:00 00013 Rapid Screening of Oxidative Stress via Ratiometric Redox-Active Biomarker Analysis Ptolemy A.S., Al Husseiny M., *Britz-McKibbin P.
11:20 End of Session

11:25 CIC Medal Lecture presented by Diethard Bohme in WCC-Room 3

BM5WCC-Room 15

Nucleic Acids: Innovations in Chemistry and Applications

Organizer(s) - Masad Damha and Robert Hudson
Chair(s) - Robert Hudson

08:00 00014 Reversible Quartet Formation of Luminescent Guanosines Martic S., Liu X.-Y., Wu G., *Wang S.
08:20 00015 Structure and Mechanism of RNA Cleaving Nucleic Acid Catalysts: Probing for the General Acid and General Base Functionality Thomas J.M., *$Perrin D.M.
08:40 00016 Modifying p19 Viral Suppressors of RNA Silencing: From Small Molecule Inhibition to Site Directed Mutagenesis *$Pezacki J.P.
09:00 00017 Reversible Photo-Regulation of a Ribozyme Using a Diffusible Effector *Sen D., Lee H.-W., Liu Y., Robinson S.G., Bandopadhyay S., Mitchell R.H.
09:40 Coffee Break
10:00 Bernard Belleau Award Lecture presented by Masad Damha

Introduction of Masad Damha by Mario Pinto

10:00 00018 Silencing Aberrant RNAs with Arabinonucleic Acids: Possible New Therapeutic Agents *$Damha M.J.
10:40 00019 Therapeutic siRNAs and Antagomirs: From Mouse to Monkey, on the Way to Man via Systemic Delivery *Manoharan M.
11:20 End of Session

11:25 CIC Medal Lecture presented by Diethard Bohme in WCC-Room 3

Sunday PM

BM6WCC-Room 15

Recent Advances in Natural Products Chemistry (Joint with OR) (joint with OR9)

Organizer(s) - Raymond Andersen and Russell Kerr
Chair(s) - Raymond Andersen

13:40 00112 Combinatorial Biosynthesis: New Opportunities for Natural Products Chemistry and Drug Discovery Shen B.
14:20 00113 Novel Approaches for Antibiotic Discovery Singh S.B.
15:00 Coffee Break
15:20 00114 Design, Synthesis and Biological Activity of Analogs of Natural Peptides Vederas J.C.
16:00 00115 Reactions of Cytochrome P450cam and other Pseudomonas putida Enzymes *$Plettner E., Rojubally A.
16:20 00116 Copper-Mediated Nuclease Activity of the Jadomycins McFarland S.A., Jakeman D.L.
16:40 End of Session

Monday AM

BM4WCC-Room 8

Latest Trends in Medicinal Chemistry, Drug Discovery and Design (Joint with OR) (joint with OR5)

Organizer(s) - Lakshmi Kotra and Christine Gottardo
Chair(s) - Christine Gottardo

08:20 00313 Investigation of the Mechanism of Binding of UDP, UDP-Galp, UDP-Galf, and UDP-[3-F]Galf to UDP-Galactopyranose Mutase by STD-NMR/Molecular Dynamics Simulation Pinto B.M.
09:00 00314 New Paramagnetic MRI Contrast Agents: Synthesis of Lanthanide(III) Complexes of Cyclen Oligopeptide Conjugates Suchy M., Wojciechowski F., Li A.X., Bartha R., $Hudson R.H.E.
09:20 00315 Hyperpolarized 13C Succinate for Biomedical MR Imaging and Spectroscopy *Chekmenev E.Y., Bhattacharya P., Norton V.A., Hovener J., $Ross B.D., Weitekamp D.P.
09:40 Coffee Break
10:00 Boehringer Ingelheim Award Lecture presented by Margaret Johnson

Introduction of Margaret Johnson by Mario Pinto

10:00 00316 NMR Studies of Molecular Mimicry in Protein-Ligand Interactions Johnson M.A.
10:40 00317 Preparation of Modified Lantibiotics: Possible Antimicrobial Agents against Gram Negative Bacteria $Yoganathan S., Pattabiraman V.R., Martin-Visscher L.A., Cobb S.L., Sit C.S., *Vederas J.C.
11:00 00318 Antibiotic Resistance via Aminoglycoside 6'-N-Acetyltransferase: Inhibition and Activation, Mechanism and Structure *$Auclair K.
11:40 End of Session

BM6WCC-Room 15

Recent Advances in Natural Products Chemistry (Joint with OR) (joint with OR9)

Organizer(s) - Raymond Andersen and Russell Kerr
Chair(s) - Russell Kerr

08:00 00319 Collectible and Culturable: Both Reasonable Options for the Discovery of New Marine Natural Products *$Wright J.L.C.
08:40 00320 Bioactive Peptides from Panamanian Marine Cyanobacteria *$Gerwick W.H., McPhail K.L., Medina R., Linington R.G., Antunes E.
09:20 00321 Exiguamine A and B, Novel Inhibitors of IDO Brastianos H.C., *Vottero E., Patrick B.O., Van Soest R., Matainaho T., Mauk A.G., $Andersen R.J.
09:40 Coffee Break
10:00 00322 Studies of the Dinoflagellate Alexandrium ostenfeldii and its Production of a Novel Class of Marine Toxins Known as the Spirolides MacKinnon S.L.
10:40 00323 The Diels-Alder Approach to Palau'amine Gleason J.L., Cernak T.A.
11:00 00324 A Novel Route to b-Lactones Anwar J., Jenkins S.I., *$Harrison P.H.M.
11:20 00325 Surprising b-Proton Exchange in the Biosynthesis of Sirodesmin PL Yu Y., *Pedras M.S.C.
11:40 End of Session

Monday PM

BM4WCC-Room 8

Latest Trends in Medicinal Chemistry, Drug Discovery and Design (Joint with OR) (joint with OR5)

Organizer(s) - Lakshmi Kotra and Christine Gottardo
Chair(s) - Lakshmi Kotra

13:00 00429 Emerging Frontiers of Designed Multiple Ligands. Rationale Design of Dual Action Nitric Oxide Synthase Inhibitors with 5HT Agonism for the Treatment of Migraine *Maddaford S., Ramnauth J., Patman J., Renton P., Annedi S., Rakhit S., Andrews J., Vanderah T., Zhang D., Majuta L., Porreca F., Garcin-Hosfield E., Bunton D., Rankin L., Stevenson C., Macdonald K., Nair S., Lee D.
13:40 00430 Design and Testing of Novel Potent Inhibitors of b Amyloid Oligomerization Roy S., *$Rauk A.
14:00 00431 Targeting Post-Translationally Modified Amino Acids with Synthetic Receptors Mahnke D.J., Whiting A.L., Fowler N.M., Hof F.
14:20 00432 Selective Ligand Design for Nuclear Receptors Shadnia H., Wright J.S., Ziebell T.
14:40 00433 Structural and Functional Proteomics of the SARS Coronavirus Johnson M.A., Almeida M.S., Serrano P., Chatterjee A., Neuman B., Joseph J., Saikatendu K., Subramanian V., Stevens J., Wilson I.A., Buchmeier M.J., Stevens R.C., Kuhn P., Wüthrich K.
15:00 Coffee Break
15:20 00434 Structure-Guided Design, Synthesis and In Vivo Characterization of Inhibitors of Enoyl ACP Reductase *Pauls H.W.
16:00 00435 Nonpeptidic Biaryl Bearing Benzylic Amines as Inhibitors of Human Cathepsin K *$Isabel E., Black W.C., Falgueyret J.-P., Mellon C., Oballa R., Percival M.D., Prasit P., Robichaud J.
16:20 End of Session

BM6WCC-Room 15

Recent Advances in Natural Products Chemistry (Joint with OR) (joint with OR9)

Organizer(s) - Raymond Andersen and Russell Kerr
Chair(s) - Russell Kerr

13:00 00436 Natural Products in a World-Out-of-Balance Cordell G.A.
13:40 00437 A Case Study: Using Plant Genomics and Microbial Metabolic Engineering for the Production of a Pharmaceutical in Microbes *$Ro D.K., Paradise E.M., Keasling J.D.
14:00 00438 Novel Constituents of Plant Cuticular Waxes: Very-Long-Chain Polyketides Wen M., *$Jetter R.
14:20 00439 Learning from Nature: Paldoxins for Environmentally Sustainable Treatments of Plant Diseases *$Pedras M.S.C.
15:00 Coffee Break
15:20 00440 New Glutathione-S-Transferase Inhibitors from Barleria prionitis Kalhari K.S., Nawaz H., *$Ata A, Samarasekera R.
15:40 00441 Secondary Metabolites Involved in the Interaction of Canola with the White Rust Fungus Albugo candida Zheng Q.A., *Pedras M.S.C.
16:00 00442 The Biosynthesis of Crucifer Phytoalexins: Unprecedented Incorporation of Indolyl-3-acetothiohydroxamic Acid Okinyo D.P.O., *Pedras M.S.C.
16:20 End of Session



Organizer(s) - Athar Ata
Chair(s) - Athar Ata

From 17:00 until 19:00

17:00 00443 Methicillin-Resistant Factor FmtA of Staphylococcus Aureus is a Penicillin-Binding Protein *$Golemi-Kotra D., Fan X., Liu Y.-H., Konermann L., Siu M.K.W.
17:00 00444 Most Recent Common Ancestor of the Plant Chalcone Synthase Superfamily Gordon G., *Suh D.-Y.
17:00 00445 Divergent Evolution of Condensing Enzymes and the Chalcone Synthase Superfamily Jiang C., *Suh D.-Y.
17:00 00446 A Thiamine Catalyzed Bioorthogonal Approach Toward Activity-Based Protein Profiling McKay C., Hoop K., Blais D, Rakic B., $Pezacki J.P.
17:00 00447 L-Lysine Biosynthesis in Plants: Characterization and Inhibition Studies of LL-Diaminopimelate Aminotransferase Clay M.D., Flegel M.D., van Belkum M.J., Marcus S.L., $Vederas J.C.
17:00 00448 Mechanism of Tocopherol Transfer by Human a-Tocopherol Transfer Protein (TTP) Investigated by FRET Zhang W.X., Frahm G., *$Atkinson J.
17:00 00449 Structure-Activity Relationships Between b-Lactams and Anthrax Lethal Factor Dabous J.R., Carbone R.A., $Siemann S.
17:00 00450 Characterization of Tetrachlorohydroquinone Reductive Dehalogenase (PcpC) in the Pentachlorophenol (PCP) Biodegradation Pathway Su Y., Chen L., $Yang J.
17:00 00451 Deciphering the Role of Zinc in Anthrax Lethal Factor through Metal-Substitution Carbone R.A., Dabous J.R., $Siemann S.
17:00 00452 Substrate Specificity of AlkA, a DNA Repair Enzyme Ramnarine A., *Berti P.J.
17:00 00453 Structure, Interactions, and Dynamics of the RING Domain from TRAF6, a Signaling Adaptor Protein Mercier P.M., Lewis M.J., Hau D.D., Saltibus L.F., Xiao W., *$Spyracopoulos L.
17:00 00454 Preparation of Glycosylated Oligodeoxyribonucleotides Yan H., Anguilar A.L.
17:00 00455 Intrinsically Fluorescent Nucleobases: Design, Synthesis and Applications *$Hudson R.H.E.
17:00 00456 A New Structural Alternative in Benzo[b]furans for Antimicrobial Activity *Chowdhury R., Khan M.W., Alam M.J., Rashid M.A.
17:00 00457 Inhibitors of Aminoacyl-tRNA Synthetases and tRNA-Dependent Amidotransferases Balg C., Huot J., Blais S., Lapointe J., *Chenevert R.
17:00 00458 New Paramagnetic MRI Contrast Agents: Magnetic (CEST) Properties of Lanthanide(III) Complexes of Cyclen Oligopeptide Conjugates Suchy M., Li A.X., Wojciechowski F., Hudson R.H.E., $Bartha R.
17:00 00459 Kinetic Study of Cis-Trans Isomerization of Model Peptides Containing Spirocyclic Sugar-Proline Hybrids Zhang K., *Schweizer F.
17:00 00460 Methodology for Stereospecific Synthesis of Oxygen Analogs of Lanthionine and b-Methyllanthionine Liu H., Pattabiraman V.R., *Vederas J.C.
17:00 00461 Divergent Route to Truncated Pancratistatin Analogues Nair J.J., *McNulty J.
17:00 00462 Antibacterial Activity-Exhibiting Natural Products from Sphaeranthus indicus Betteridge J., Schaub E., *$Ata A., Samarasekera R.
17:00 00463 Efficient Synthesis of the first Naturally Occurring Indolyl-3-methylthiol Carbamate Phytoalexin Brussalexin A Zheng Q.A., *Pedras M.S.C.
17:00 00464 Bioactive Chemical Constituents of Artocarpus nobilis Zahid S., *$Ata A., Samarasekera R.
17:00 00465 Biologically-Active Terpenoidal Glycosides from Nauclealatifolia Udenigwe C.C., *$Ata A.
17:00 00466 Exploration of the Metabolome of Cardamine diphylla (Michx.) Wood *$Montaut S., Bleeker R.
17:00 00467 The Total Synthesis of Montanin A and Teuscorolide *Liu H.J., Chen I.C., Wu Y.K., Zhu J.L.
17:00 00468 1,4-Triazole Formation: Trapping Terminal Di-, Tri-, and Tetraynes with Benzyl Azide Luu T., Vallee D., Ha E., *Tykwinski R.R.

19:00 End of Session

Tuesday AM


Analytical Separations by Capillary Electrophoresis (Joint with AN) (joint with AN2)

Organizer(s) - Douglas Craig
Chair(s) - Douglas Craig

08:00 Joint with Analytical Chemistry Division - See AN2

11:20 End of Session

BM4WCC-Room 15

Latest Trends in Medicinal Chemistry, Drug Discovery and Design (Joint with OR) (joint with OR5)

Organizer(s) - Lakshmi Kotra and Christine Gottardo
Chair(s) - Christine Gottardo

08:20 00687 Synthesis of Natural Products that Incorporate Hexahydropyrroloindolines as Precursors to a Library of Amanitins and Phalloidins May J.P., *$Perrin D.M.
09:00 00688 Identification of New HIV-1 Protease and Fungal 14a-Demethylase Inhibitors: Lead Compound Discovery and Optimization Using Click Chemistry Hein J.E., Pitram S.M., Tripp J.C., Whiting M, Fokin V.V., $Sharpless K.B.
09:20 00689 A Supramolecular Approach to DNA Targeting and Anti-Cancer Drug Design *Petitjean A., Lehn J.-M., Verrelle P.
09:40 Coffee Break
10:00 00690 Design and Synthesis of Bis-Indoles for the Treatment of Alzheimer's Disease *$Weaver D., Carter M., Jacobo S., Lu E.
10:40 00691 Synthesis of Diosgenyl Saponin Analogues and their Anti-Cancer Properties Kaskiw M.J., Tassotto M.L., Th'ng J., Jiang Z.-H.
11:00 00692 Triciferols: Hybrids of Vitamin D and Trichostatin A as Anticancer Compounds Gleason J.L., Quach T.D., White J.H., Tavera-Mendoza L.E.
11:20 End of Session

11:25 Montreal Medal Lecture presented by Joseph Hubert in WCC-Room 3

Tuesday PM

BM3WCC-Room 11

Enzyme Structure-Function

Organizer(s) - John Honek
Chair(s) - John Honek

13:40 00821 IMP Dehydrogenase and the Dynamics of Drug Selectivity *$Hedstrom L., Yang W.
14:20 00822 Inhibition of the Thiamin Diphosphate-Dependent Enzyme MenD, a Proposed Target for Anti-Tubercular Agents *Palmer D.R.J., Fang M., Ho K., McNeil M.
14:40 00823 Mutational Analysis of the Active Site Flap of Mandelate Racemase *$Bearne S.L., Bourque J.R.
15:00 Coffee Break
15:20 00824 Control of Nitric Oxide Synthase Activity by Calmodulin and a Caged Inhibitor $Guillemette J.G., Spratt D.E., Montgomery H.J., Newman E., Perdicakis B., Jervis E.J.
16:00 00825 On the Substrate Specificity of Nucleotidylyltransferases *$Jakeman D.L., Timmons S.C., Knowles S.A., Mosher R.H.
16:20 00826 A Detailed Evaluation of the Efficacy of Filter/Filter and Filter/Edited Experiments in Multi-Dimensional, Multi-Nuclear NMR Spectroscopy McKay R.T., Spryacopoulos L., Robertson I., Sykes B.D.
16:40 00827 Insights into the Substrate Specificity, Inhibition, and Metal Requirement of the Anthrax Lethal Factor Carbone R.A., Dabous J.R., Courchesne K., Siemann S.
17:00 End of Session

Wednesday AM

BM7WCC-Room 8


Organizer(s) - Athar Ata
Chair(s) - Jim Diakur

08:00 00994 Synthesis and Biological Evaluation of Stabilized Functionalized Derivatives of Prodigiosin *Thompson A.
08:40 00995 Determination of Biogenic Amines in Foods and Alcoholic Beverages by Ion Chromatography Babcock C., *$DeBorba B.M.
09:00 00996 An Alternative Approach to the Direct Fluorination of Aromatic Amino Acids Using Elemental Fluorine: Synthesis of a New PET Tracer For Tumor Imaging $Behnam Azad B., Farncombe T., Saab C., Schrobilgen G.J., *Chirakal R.V.
09:20 Coffee Break
10:00 00997 How the Anthracycline Cardioprotective Drug Dexrazoxane Works in Cardiac and Tumor Cells *$Hasinoff B.B.
10:40 00998 Effect of Mating on Pheromone Biosynthesis in Female Tenebrio Molitor (Coleoptera: Tenebrionidae) *Mangat J., $Vanderwel D.
11:00 End of Session

Wednesday PM

BM3WCC-Room 8

Enzyme Structure-Function

Organizer(s) - John Honek
Chair(s) - Guy Guillemette and John Honek

13:00 01076 Enzyme Evolution for New Function: Microbial Adaption to Environmental Chemicals *$Wackett L.P.
13:40 01077 Loop Dynamics: Coupling Substrate-Specificity to Function in Flavoproteins *$O'Neill M.A.
14:00 01078 Enolpyruvyl Activation by Enolpyruvyl Shikimate 3-Phosphate Synthase Clark M.E., Zhang F., Berti P.J.
14:20 01079 Active Site Studies of Glyoxalase I in Escherichia coli and Pseudomonas aeruginosa Sukdeo N., Su Z.D., $Honek J.F.
14:40 01080 The First Structure of a Complete Multifunctional Biotin-Dependent Enzyme: The Pyruvate Carboxylase Tetramer to 2.0 ° Resolution St-Maurice M., Reinhardt L., Cleland W.W., $Rayment I., Surinya K., Wallace J.
15:00 Coffee Break
15:20 01081 How GTP Binds to the GTP-Specific Form of Succinyl-CoA Synthetase *$Fraser M.E., Hayakawa K., Hume M.S., Ryan D.G., Brownie E.R.
16:00 01082 Investigative Studies of Thiostrepton-Resistance rRNA Methyltransferase and its Cognate Antibiotic Thiostrepton Hang P.C., Daub E., $Honek J.F.
16:20 01083 The Effects of Acquiring Extremely Rapid or Highly Resolved Non-Uniform Data Schemes on the Resultant Resolution, Signal-to-Noise, and Line Shape in Multi-Dimensional, Multi-Nuclear NMR Spectroscopy McKay R.T.
16:40 End of Session

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